Logigian and Steere showed intravenous
ceftriaxone to be effective for neurologic Lyme disease in patients
previously treated with oral and intravenous antibiotics. The majority
(56% - 83%) of neurologic Lyme disease patients treated by Logigian
and Steere had been previously treated with antibiotics and yet were
successfully treated.[1,2] Retreatment was successful even if treated
previously with intravenous antibiotics, including, “One of
the cases had been treated with iv penicillin for 6 weeks previously.
Three patients had been treated with iv ceftriaxone for 2 weeks, 1
for early neuroborreliosis, 1 for cardiac conduction block, and 1
as initial treatment for Lyme encephalopathy 3 years prior to study
entry.”[2]
Reference
1. Logigian EL, Kaplan RF, Steere AC. Chronic neurologic manifestations of Lyme disease. N Engl J Med 1990; 323:1438 44.
2. Logigian EL, Kaplan RF, Steere AC. Successful treatment of Lyme encephalopathy with intravenous ceftriaxone. J Infect Dis 1999 Aug;180(2):377-83.
Copyright: Dr. Daniel
Cameron
Editor: Lyme Research and Practice
