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British Medical Journal Rapid response to: Alison Tonks LymeWars BMJ 2007; 335: 910-912

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“Most controversies occur when there is little evidence. The total number of subjects enrolled in published RCTs to date amounted to only 221 subjects.

This same size –is far too small to draw broad conclusions suppressing the only treatment option known to be effective for Lyme disease. Moreover, the results of the studies are limiting and conflicting. When evidence is uncertain and controversy exists, it is critical for the medical community to be able to evaluate conflicting positions, the basis for the medical evidence cited, study criteria, professional agendas and conflicts of interests that may exist. Only by airing these different points of view will the medical and scientific community reach a better understanding of controversial topics such as chronic Lyme disease. Meanwhile, physicians must be able to exercise their clinical judgment and patients should be provided with treatment options.”

http://www.bmj.com/cgi/eletters/335/7626/910#181433

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